Tolterodine tartrate
CAS No.
124937-52-6
Reference product
Detrusitol/PFIZER
Polymorphic form
Crystalline Form I
Therapeutic Area
Genito-urinary system & sex hormones
Status
commercial
EU DMF readiness
✓
CEP
✓
Other documentation
Canadian DMF
Drug description:
Tolterodine tartrate is a diphenylmethane derivative, acts as an anticholinergic agent.
It is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
It is formulated as film coated tablets for oral route of administration.
Mechanism of action:
Tolterodine is a competitive, specific muscarinic receptor antagonist with a selectivity for the urinary bladder over salivary glands in vivo. One of the tolterodine metabolites (5-hydroxymethyl derivative) exhibits a pharmacological profile similar to that of the parent compound. In extensive metabolizers this metabolite contributes significantly to the therapeutic effect.
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