Sodium salicylate

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We are a Poland-based CDMO and manufacturer of active pharmaceutical ingredients (APIs), that is proceeding with a $45-million manufacturing expansion of its main API plant in Starogard Gdanski to include HPAPI and cryogenic technologies and investments in a pilot plant and R&D capabilities. We expect to extend our operations starting from 2024 with full completion scheduled for Q3 2024.

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Polpharma API CDMO (Contract Development and Manufacturing Organization) supports emerging and large pharmaceutical customers in the development and commercialization of their small-molecule APIs clinical candidates thanks to +70 years of experience in process development, scale-up, and cGMP manufacturing of small molecule APIs in volumes ranging from kilos to tens of tons.

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We are a Poland-based CDMO and manufacturer of active pharmaceutical ingredients (APIs) that is proceeding with a $35-million facility expansion of its main API plant in Starogard Gdanski to include HPAPI and cryogenic technologies and investments in a pilot plant and R&D capabilities. We expect to extend our operations starting from Q1 2024, with full completion scheduled for Q3 2024.

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Sodium salicylate

CAS No.

54-21-7

Reference product

N/A

Polymorphic form

Monoclinic form (space group P21/m)

Therapeutic Area

Alimentary tract & metabolism

Status

commercial

EU DMF readiness

✓

US DMF readiness

026873

Other documentation

Japanese DMF

Drug description

Sodium salicylate is the sodium salt of salicylic acid. It is used as an analgesic and antipyretic.
It is also a potential replacement for aspirin for people sensitive to it.

Mechanism of action:

Sodium salicylate is a non-selective COX inhibitor. It inhibits the two isoforms of cyclooxygenase, COX-1 and COX-2. sodium salicylate irreversibly acetylates cyclooxygenases thereby inhibiting prostaglandin synthesis and associated inflammation and pain.

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