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Lamotrigine is an anti-epileptic agent used alone or in combination with other medications to treat partial seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome; for conversion to monotherapy in adults with partial seizures. It is also indicated for the treatment of Bipolar I disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adult.
It is formulated as chewable tablet, tablet for suspension and tablet for oral administration.
Mechanism of action:
Lamotrigine is a use- and voltage-dependent blocker of voltage gated sodium channels. It inhibits sustained repetitive firing of neurons and inhibits release of glutamate (the neurotransmitter which plays a key role in the generation of epileptic seizures). These effects are likely to contribute to the anticonvulsant properties of lamotrigine. In contrast, the mechanisms by which lamotrigine exerts its therapeutic action in bipolar disorder have not been established, although interaction with voltage gated sodium channels is likely to be important.
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