EU DMF readiness
Clopamide is a piperidine and sulfamoylbenzamide derivative acts as an antidiuretic agent.
Clopamide is indicated for treatment of hypertension.
It is formulated as tablet for oral route of administration.
Mechanism of action:
Clopamide acts at the proximal convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus interferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.
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for the R&D and Production of highly active substances
with an OEL value of 10 ng/m3 (OEB 6).
The HP API investment includes separate process
laboratories (PDL), analytical laboratories (ADL)
with the possibility of performing Quality Control
analyses, and a GMP kilo-lab production line with
volume up to 1.5 kg with potential volume increase.