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Polymorphic form

Form II

Therapeutic Area

Cardiovascular system



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Drug description:

Carvedilol is a carbazole derivative acts as anti-hypertensive agent.
Carvedilol is indicated for the management of essential hypertension. It is also indicated to reduce cardiovascular mortality in clinically stable patients who have survived the acute phase of a myocardial infarction and have a left ventricular ejection fraction. Carvedilol is also indicated for the treatment of tachycardiac atrial fibrillation.
It is formulated as tablets or film coated tablets for oral route of administration.

Mechanism of action:

Carvedilol acts as a nonselective beta-adrenoceptor blocking agent and as an alpha 1-adrenoceptor blocker. It’s beta-adrenergic receptor (beta-1 and beta-2 adrenergic receptors) blocking ability decreases the heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its alpha adrenergic (alpha-1) receptor blocking properties. Carvedilol and its metabolites also prevent OH- radical-induced decrease in sarcoplasmic reticulum Ca2+-ATPase activity. Therefore, carvedilol and its metabolites may be beneficial in chronic heart failure by preventing free radical damage.

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