Acenocumarol
CAS No.
152-72-7
Reference product
N/A
Polymorphic form
Therapeutic Area
Cardiovascular system
Status
commercial
EU DMF readiness
✓
Drug description:
Acenocumarol is a coumarin derivative acts as an anticoagulant agent. It is used for the treatment of atrial fibrillation, atrial flutter, atrial tachycardia, deep vein thrombosis, dyskinesia, left ventricular dysfunction, myocardial infarction, pulmonary embolism, thromboembolic disease.
It is formulated as tablets for oral route of administration.
Mechanism of action:
Acenocumarol is a vitamin K antagonist; inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation.
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