Xylometazoline is a nasal vasoconstricting decongestant drug.
It is indicated for the temporarily relieves nasal congestion due to cold, hay fever or other respiratory allergies. It is indicated in treatment of acute allergic rhinitis, sinusitis, pollinosis, otitis media (to reduce edema of the nasopharyngeal mucosa).
It is formulated as spray for nasal route of administration.
Mechanism of action:
Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist.
It induces systemic vasoconstriction, thereby decreasing nasal congestion. The sympathomimetic action of xylometazoline constricts the smaller arterioles of the nasal passages, producing a prolonged decongesting effect.