Available EU DMF/CEP
EU DMF
CEP
API Status
Commercial
Pipeline
Therapeutic Category
Alimentary tract & metabolism
Anti-infectives for systemic use
Antipyretic, analgesic and anti-inflammatory
Antineoplastic & immunomodulating agents
Blood & blood forming organs
Cardiovascular system
Genito-urinary system & sex hormones
Injectable forms
Musculo-skeletal system
Nervous system
Opthalmological preparations
Respiratory system
Available US DMF
US DMF
Available Japanese/Chinese DMF
Japanese DMF
Chinese DMF
Korean DMF

Nefopam hydrochloride*

CAS No.

23327-57-3

Innovator/marketer

Acupan

Polymorphic form

Therapeutic Area

Nervous system

Status

Commercial

EU DMF readiness

Drug description:

Painkilling medication, primarily used to treat post-surgery moderate to severe, acute or chronic pain, also in the prevention of shivering.

Mechanism of action:

Effects in the brain and spinal cord to relieve pain via rather unique mechanisms. Firstly it increases the activity of serotonin, norepinephrine and dopamine, neurotransmitters involved in, among other things, pain signalling. Secondly it modulates sodium and calcium channels thereby inhibiting the release of glutamate, a key neurotransmitter involved in pain processing.

* IPOCHEM API Manufacturing Site

DISCLAIMER
Products protected by valid patents are not offered for commercial sale in countries where the sale of such products constitutes patent infringement but are offered solely for uses reasonably related to the development and submission of information under a law regulating the manufacture, use or sale of drugs. It is within the buyer’s responsibility and liability to check the patent situation of the product in the imported market(s).

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