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Linagliptin

CAS No.

668270-12-0

Innovator/marketer

Tradjenta

Polymorphic form

Mix of form A & B

Therapeutic Area

Alimentary tract & metabolism

Status

Pipeline

EU DMF readiness

US DMF readiness

029844

Other documentation

Chinese DMF

Drug description:

Linagliptin is an anti-diabetic agent and anti-hyperglycemic agent.
Linagliptin is indicated for the treatment of type 2 diabetes mellitus to improve glycemic control in adults.
It is formulated as tablets and film coated tablets for oral route of administration.


Mechanism of action:

Linagliptin acts as dipeptidyl peptidase-4 (DPP-4) inhibitor. The enzyme DPP-4 cleaves dipeptides from the N-terminal ends and interferes with the plasma level of bioactive peptides. Increase free fatty acid influx promotes liver inflammation. The drug candidate by inhibiting DPP-4 reduces the level of inflammatory cytokines such as TNF-alpha and interferon-gamma.

DISCLAIMER
The above product is presented solely for informational purposes and does not constitute an offer in any sense. Products under patent (SPC) protection in Poland and/or other countries are not offered until expiration of the corresponding IP right.

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