Linagliptin is an anti-diabetic agent and anti-hyperglycemic agent.
Linagliptin is indicated for the treatment of type 2 diabetes mellitus to improve glycemic control in adults.
It is formulated as tablets and film coated tablets for oral route of administration.
Mechanism of action:
Linagliptin acts as dipeptidyl peptidase-4 (DPP-4) inhibitor. The enzyme DPP-4 cleaves dipeptides from the N-terminal ends and interferes with the plasma level of bioactive peptides. Increase free fatty acid influx promotes liver inflammation. The drug candidate by inhibiting DPP-4 reduces the level of inflammatory cytokines such as TNF-alpha and interferon-gamma.