Chlorpromazine hydrochloride is an anti-emetic and antipsychotic agent.
It is indicated for the treatment of schizophrenia, to control nausea and vomiting, for relief of restlessness and apprehension before surgery, acute intermittent porphyria, as an adjunct in the treatment of tetanus, to control the manifestations of the manic type of manic-depressive illness and for relief of intractable hiccups.
It is formulated as sugar coated tablets for oral route of administration.
Mechanism of action:
Chlorpromazine has depressant actions on the Central Nervous System, with alpha-adrenergic blocking and anticholinergic activities. It inhibits Dopamine and Prolactin release-inhibitory factor, thus stimulating the release of Prolactin. It increases the turnover of Dopamine in the brain. It has anti-emetic, anti-puritic, serotonin-blocking and weak anti-histamine properties and slight ganglion blocking activity. It inhibits the heat regulating center in the brain, and is analgesic and can relax skeletal muscle. Due to its action on the autonomic system it produces vasodilatation, hypotension and tachycardia. Salivary and gastric secretions are reduced.