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Brexpiprazole

CAS No.

913611-97-9

Innovator/marketer

Rexulti

Polymorphic form

Polymorphic form I

Therapeutic Area

Nervous system

Status

Pipeline

EU DMF readiness

US DMF readiness

032347

Drug description:

Brexpiprazole is an atypical antipsychotic and adjunctive antidepressant.
Brexpiprazole is indicated for the treatment of schizophrenia, as a maintenance treatment of schizophrenia in adults and as an adjunctive treatment of major depressive disorder (MDD).
It is formulated as tablets and film coated tablets for oral route of administration.

Mechanism of action:

Brexpiprazole is a serotonin-dopamine activity modulator (SDAM) that acts as a partial agonist at 5-HT1A and dopamine D2 receptors at similar potency, and an antagonist at 5-HT2A and noradrenaline alpha1B/2C receptors. Dopamine partial agonist distinguishing characteristic is their mechanism of action. These drugs are partial agonists at dopamine D2/D3 receptors and can act as dopaminergic stabilizers, performing as dopamine antagonists in conditions of dopamine hyperactivity and exhibiting dopamine agonist properties in states of hypoactivity.

DISCLAIMER
The above product is presented solely for informational purposes and does not constitute an offer in any sense. Products under patent (SPC) protection in Poland and/or other countries are not offered until expiration of the corresponding IP right.

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