Avanafil is a vasodilator.
It is indicated to treat erectile dysfunction in adult men. In order for avanafil to be effective, sexual stimulation is required.
It is formulated as tablets for oral route of administration.
Mechanism of action:
Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5. When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Avanafil has no effect in the absence of sexual stimulation.