Available EU DMF/CEP
EU DMF
CEP
API Status
Commercial
Pipeline
Therapeutic Category
Alimentary tract & metabolism
Anti-infectives for systemic use
Antipyretic, analgesic and anti-inflammatory
Antineoplastic & immunomodulating agents
Blood & blood forming organs
Cardiovascular system
Genito-urinary system & sex hormones
Injectable forms
Musculo-skeletal system
Nervous system
Opthalmological preparations
Respiratory system
Available US DMF
US DMF
Available Japanese/Chinese DMF
Japanese DMF
Chinese DMF
Korean DMF

Acenocoumarol*

CAS No.

152-72-7

Innovator/marketer

N/A

Polymorphic form

Therapeutic Area

Cardiovascular system

Status

Commercial

EU DMF readiness

Drug description:

Acenocoumarol is a coumarin derivative acts as an anticoagulant agent. It is used for the treatment of atrial fibrillation, atrial flutter, atrial tachycardia, deep vein thrombosis, dyskinesia, left ventricular dysfunction, myocardial infarction, pulmonary embolism, thromboembolic disease.
It is formulated as tablets for oral route of administration.

Mechanism of action:

Acenocoumarol is a vitamin K antagonist; inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation.

* IPOCHEM API Manufacturing Site

DISCLAIMER
Products protected by valid patents are not offered for commercial sale in countries where the sale of such products constitutes patent infringement but are offered solely for uses reasonably related to the development and submission of information under a law regulating the manufacture, use or sale of drugs. It is within the buyer’s responsibility and liability to check the patent situation of the product in the imported market(s).

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